DRUGS company GlaxoSmithKline closed its factory in Scotland yesterday after an explosion that left four people injured.

The blast occurred just before 7am at Glaxo's plant in Irvine, North Ayrshire.

Glaxo, which employs more than 1,000 people at its plant in Barnard Castle, County Durham, said last night it did not believe the incident would affect production elsewhere.

A spokesman at Barnard Castle said: "The Irvine plant is a primary site, which mixes raw materials and produces bins of powder or liquid.

"The Barnard Castle plant is a secondary site, which gets raw materials from primary sites and puts them together to form tablets or sprays and then packages them.

"We don't get our materials from Irvine and so there will be no impact on the Barnard Castle plant."

About 700 people are employed at the Irvine plant, but only 20 people were working in the factory when the explosion happened.

Two men were taken to the hospital suffering from shock and smoke inhalation and two were treated for burns.