Extensive works will take place on the railway between Northallerton and York over both May bank holiday weekends.
The planned engineering work will affect the East Coast Main Line between May 2 and 4 and again from May 23 to 25.
Network Rail said the upgrades are designed to improve the reliability and long-term resilience of the line.
Jason Parrish, head of planning at Network Rail, said: "These improvements are an important investment in the long term resilience of the East Coast Main Line.
"Renewing life expired equipment, improving drainage and strengthening embankments all help reduce delays and protect the railway.
"While there is never a good time to close the railway, scheduling the work over the bank holidays allows us to minimise disruption and deliver best value.
"We’re grateful to passengers for their understanding while we complete this vital work."
The works include track, structures, and drainage upgrades.
Bridge beams will be installed at Landing Lane in York as part of the wider York Central regeneration project, a £135 million infrastructure scheme being delivered on behalf of Homes England and Network Rail.
Three sets of points will be renewed at Tollerton to improve reliability and reduce future maintenance disruption.
Other works include embankment stabilisation in the Tollerton area and drainage renewal near Shipton.
The work means changes to East Coast Main Line passenger services over both affected weekends, including rail replacement bus services.
A spokesperson for the train operating companies said: "We’re working closely with Network Rail to keep passengers moving while this important work takes place.
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"Although journeys will take longer and involve rail replacement coaches or buses on some routes, these upgrades will mean more reliable services in the long term.
"We’re asking customers to plan ahead, check before travelling and allow extra time for their journeys."
Separately, Transpennine Route Upgrade engineering work will continue to affect services between Huddersfield and Leeds throughout May and June.
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