The Gunners are in need of the points to strengthen their grip on the fourth and final Champions League place ahead of Everton.
And Newcastle, who are in danger of slipping out of the Premier League's top ten, are able to call on both Sissoko and Remy from the start at the Emirates.
The latter has been included at the top of the system, meaning Shola Ameobi is left out after his goal in the defeat to Swansea City.
Arsenal (4-2-3-1): Szczesny; Sagna, Mertesacker, Koscielny, Monreal; Arteta, Ramsey; Cazorla, Ozil, Podolski; Giroud. Subs: Fabianski, Jenkinson, Vermaelen, Kallstrom, Flamini, Rosicky, Sanogo.
Newcastle United (4-4-1-1): Krul; Debuchy, Williamson, Coloccini, Dummett; Gosling, Anita, Tiote, Gouffran; Sissoko; Remy. Subs: Elliot, Haidara, Yanga-Mbiwa, S Taylor, Obertan, Armstrong, Shola Ameobi.