The disappointing 4-0 defeat at Southampton means Newcastle have now lost three of their last four and accordingly they're 3/1 outsiders with Stan James to turn things around against Manchester United.
Despite a poor season, the champions have the top flight's best away record so they're BetVictor's even money favourites, while bet365 post 13/5 against an inconclusive affair and it's 18/5 (BetVictor) to be a score draw.
More accurately, Winner.com chalk it up at 6/1 to finish 1-1, it's 5/1 at bet365 to be all square at the end of each half and Stan James rate the Magpies at 2/1 in their 'Draw No Bet' market.
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However, Alan Pardew's troops have only drew four times in 32 outings this season so punters are likely to be expecting one of the teams to come out on top and home fans might believe that will be Newcastle, given that they won the reverse fixture at Old Trafford in December.
That finished 1-0, a result that's 13/1 courtesy of BetVictor in this encounter, Paddy Power price Pardew's men at 9/2 to shade it by a one-goal margin and it's 15/2 (William Hill) for Newcastle to again prevail following an even first period.
The 2-1 home defeat to West Ham was a real body blow for Sunderland who have now taken just one point from their last six Premier League matches and worryingly for Gus Poyet's beleaguered side, bookies are now confident that they'll relinquish their top-flight status, BetVictor making them 1/2 for the drop.
Layers are similarly convinced that the Black Cats will fail to boost their survival chances as they head to Tottenham for the first of four fixtures on the spin against teams in the top six, William Hill posting 8/15 against a sixth league defeat in seven for Sunderland, who are Ladbrokes's 13/2 underdogs to land a vital three points.
Stan James offer 10/3 about a stalemate at White Hart Lane, where a score draw is a 9/2 chance at bet365 and Winner.com mark 15/2 against a 1-1 scoreline.
However, the hosts have lost four of their last six, a statistic that might encourage a few bets on Sunderland at 19/1 (BetVictor) to grab the only goal. That would be good news for anyone backing an away win to nil at 11/1 via Skybet or BetVictor's 11/10 about the game featuring under 2.5 goals, the first of which is 11/1 at betway to come from Fabio Borini.
Despite upsetting the odds to win at Brighton last Saturday, Middlesbrough are slight outsiders at 19/10 with bet365 to emerge triumphant as they return to the Riverside to face Derby (17/10, William Hill).
A fourth stalemate in six for Aitor Karanka's side is a 12/5 chance at Skybet, BetVictor post 17/4 against it being all square at the end of each half and it's 6/1 via Ladbrokes for the two teams to net once-each. Nevertheless, the Rams' away record in 2014 has been far from convincing and so Boro are likely to fancy their chances.
They're 17/5 courtesy of BetVictor to come out on top by one and 6/1 at Stan James to tag a victory on to the back of a level first period. Winner.com meanwhile, rate a 2-1 triumph at 10/1 and bet365 price Albert Adomah, who has three in his last two, at 17/2 to notch first.
Hartlepool's trip to Portsmouth is 37/20 (betway) to go the way of the visitors and 9/4 with Skybet to be Inconclusive.
Odds supplied by www.betrescue.com
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