Sunderland should be well rested for the FA Cup tie against Southampton following the postponement of their midweek trip to Man City, but the
are slight outsiders at 2/1 with Stan James to reach the quarter final at the first attempt.
Saints arrive as William Hill's slight 29/20 favourites but as the pair's two Premier League meetings this term ended all square, there's expected to be cash for the stalemate at 12/5 via bet365 while a repeat of the 2-2 scoreline from January's Stadium of Light contest can be backed at 16/1 courtesy of BetVictor.
The same firm offer 17/1 about Gus Poyet's men again recovering from a half-time deficit to finish level, bet365 post 7/2 against a score draw and Winner.com rate Sunderland at 5/4 in the Draw No Bet market.
The Black Cats also benefit from a goal start in bet365's handicaps at 3/5, but home supporters will recall that the pair also met in the Capital One Cup earlier this season, with Poyet's charges winning 2-1 and they're 11/1 (BetVictor) to replicate that result.
Any triumph by a one-goal margin is 19/5 at Ladbrokes, Paddy Power price Sunderland at 5/1 to come out on top but also concede and Stan James quote the Black Cats at 7/1 to prevail despite an even first period.
Where goals are concerned, Betway post even money against a match tally of three or more, it's 5/6 at BetVictor for both teams to get on the scoresheet and Stan James go 5/4 about Poyet's side being the first team to find the net.
Skybet, meanwhile, quote Fabio Borini at 9/1 to grab that opener and it's even money (Stan James) for the deadlock to be broken inside the 27-minute mark.
Middlesbrough have played out three consecutive goalless encounters and they're 9/1 at bet365 to make it four on the spin as they travel to Watford. The same firm quote 5/2 for any stalemate at Vicarage Road, where a more exciting score draw is 18/5 via BetVictor and Stan James post 4/1 against both halves finishing all square.
Enjoying home advantage, the Hornets are William Hill's 5/4 favourites for the points while Aitor Karanka's troops are a 13/5 chance at BetVictor to snap a four-match winless streak and Paddy Power price them at 6/4 in the 'Draw No Bet' market.
As underdogs, Boro are handed a goal start by betway in the handicaps at 13/20 but Boro prevailed in the corresponding fixture last term and some might fancy a repeat of the 2-1 scoreline from that October 2012 contest at 13/1 (BetVictor).
Boro's recent lack of goals means one or two might prefer a 1-0 away victory at 10/1 courtesy of Ladbrokes, especially as it's odds-on at 8/11 with Stan James for the match to produce fewer than three goals and, in a potentially tight affair, Winner.com offer 7/1 about Karanka's charges shading it following an even first period.
Having gone four games without getting on the scoresheet, Boro will be looking to Danny Graham for attacking inspiration and the loan striker is a tasty 9/1 at betway to notch first.
In League Two, Hartlepool have been backed in to 7/5 at bet365 to get the better of visiting Newport and it's 12/5 with Skybet to be a draw.
Odds supplied by www.betrescue.com
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