Despite consecutive cup victories, including a Capital One Cup semi-final triumph against Manchester United, Sunderland head to fellow strugglers Fulham as slight outsiders at 12/5 via BetVictor.
Meanwhile, betway post 5/4 against a home win and Stan James rate it at 12/5 to finish all square.
The Black Cats have shared the spoils in three of their last four on the road so there's likely to be cash for an inconclusive affair, as well as a goalless stalemate at 11/1 (Skybet).
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Similarly, a score draw at 7/2 with BetVictor is set to prove popular alongside bet365's 9/2 about the teams being inseparable at the interval and final whistle.
From some firms, including Stan James, Gus Poyet's men receive a goal start in the handicaps at 8/11 but the Black Cats will be brimming with confidence on the back of Tuesday's success and they'll consider this a great chance to boost their survival hopes.
They're 19/4 (BetVictor) to nick it by one, bet365 mark 11/1 against the Black Cats grabbing the only goal and it's 13/2 courtesy of William Hill for Poyet's charges to secure the points following an even first half. Fabio Borini meanwhile, is a 9/1 chance at Winner.com to follow his midweek winner with the opener here.
Newcastle were eliminated from the FA Cup at the hands of Cardiff last weekend and the Magpies aren't expected to bounce back tomorrow, bet365 rating them as 9/2 underdogs, despite home advantage, as they entertain title favourites Manchester City.
The high-flying visitors are 7/10 at William Hill to secure a maximum haul while Alan Pardew's side are 3/1 to hold them to land a respectable share of the spoils at St James's Park, where BetVictor chalk a score a draw up at odds of 4/1.
Also potentially of interest to home fans could be BetVictor's 14/5 marked against United in the Draw No Bet market, but although Newcastle have lost nine on the spin against City, there will still be some supporters fancying their team to upset the odds.
For them, bet365 quote a generous 16/1 about a 2-1 Magpies triumph, betway make Pardew's men 15/2 to come out on top but also concede and it's 7/1 courtesy of Stan James for Loic Remy to net first.
Middlesbrough couldn't get the better of Hull in the cup last weekend but bookies tentatively fancy them to continue their improvement in the Championship, BetVictor pricing them at 13/8 to return from Blackpool (2/1, Skybet) three points better off.
Bet365 rate a stalemate at 12/5 and Ladbrokes offer 6/1 about the Bloomfield Road contest finishing 1-1 but the Seasiders are in freefall at present so Aitor Karanka's men will be confident of emerging victorious.
They're 7/1 at Stan James to grab the only goal, Winner.com post 12/1 against Boro netting twice without reply and Paddy Power mark 16/5 against any away success 'to nil'.
Betway quote odds of 7/10 for the match to produce fewer than three goals, Boro are 10/3 via BetVictor to lead after both 45 and 90 minutes while Marvin Emnes is a 15/2 chance at bet365 to break the deadlock.
In League Two, Hartlepool entertain promotion-chasing Rochdale and it's 13/8 courtesy of William Hill for a home win.
Odds supplied by www.betrescue.com
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